Abstract: Correlation between SULT1A1 Arg213His Gene Polymorphisms and Uterine LeiomyomasChao ZHOU1, Lin LIN2, Yingzi ZHANG1, Tianhe XU3, Leilei ZHANG1Correspondence to: Yingzi ZHANG, E-mail: zhangyingzihello@163.com1Department of Gynecology and Obstetrics, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, China2School of Health Supervision, Binzhou Medical University, Yantai 264003, China3Institute of Statistical Research of Chinese Hospital, Binzhou 256603, ChinaThis work was supported by a grant from the Priming Scientific Research Foundation of Binzhou Medical University (Grant no.BY2007KYQD07)Abstract Objective: To study the correlation between polymorphisms of SULT1A1 with the risk of uterine leiomyoma interac-tion among Han Chinese in Northern QiLu. Methods: Arg213His genotypes of the SULT1A1 gene were detected using polymerasechain reaction-restriction fragment length polymorphism in a case-control study. A total of 123 cases of uterine leiomyomas and 123controls were included. Multivariate logistic regression analysis was used to estimate the risk of developing uterine leiomyomas associ-ated with environmental exposures of the SULT1A1 genotype. Results: ( 1 ) The SULT1A1 polymorphisms of the Arg/Arg, Arg/His,and His/His genotypes in the uterine leiomyoma group and the control group were significantly different ( P = 0.011 ); ( 2 ) Comparedwith that of the Arg/Arg genotype, the risk of the Arg/His was genotype and His/His was both increased, by 2.321 times and 1.985times ( P = 0.003 and P = 0.468 ). ( 3 ) The risk was significantly higher among uterine leiomyoma patients with the His allele ( OR ad-justed = 2.296, 95 % CI 1.325-3. 978, P = 0.003 ). Conclusion: SULT1A1 polymorphism of the Arg213His genotype may be associatedwith increased uterine leiomyomas among Han Chinese in Northern QiLu. SULT1A1 polymorphism of the Arg213His genotype increas-es the risk of developing uterine leiomyomas.Keywords SULT1A1; Uterine leiomyoma; Gene; Polymorphism